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Bioinformatics: A Practical Guide to the Analysis of Genes by Andreas D. Baxevanis, B. F. Francis Ouellette

By Andreas D. Baxevanis, B. F. Francis Ouellette

Delivering biologists with the trendy instruments to unravel functional difficulties in series information research and administration, this revised and up to date variation bargains a assessment of the fundamental strategies, besides discussions and comparisons of the to be had databases.

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Additional info for Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins Second Edition (Methods of Biochemical Analysis)

Sample text

Previously, it was difficult to reliably cite the translated product of a given coding region feature, except BIOSEQs: SEQUENCES by its gi number. This limited the usefulness of translated products found in BLAST results, for example. These sequences will now have the same status as protein sequences submitted directly to the protein databases, and they have the benefit of direct linkage to the nucleotide sequence in which they are encoded, showing up as a CDS feature’s /protein id qualifier in the flatfile view.

Although a disease that occurs in humans may not be found in exactly the same form in animals, often an animal disease shares enough attributes with a human counterpart to allow data gathered on the animal disease to be used to make inferences about the process in humans. Mathematical models describing the forces involved in musculoskeletal motions can be built by imagining that muscles are combinations of springs and hydraulic pistons and bones are lever arms, and, often times, 19 20 T H E N C B I D ATA M O D E L such models allow meaningful predictions to be made and tested about the obviously much more complex biological system under consideration.

Once again, the data model must allow the minimum information set to come in as a citation, be matched against MEDLINE, and then be replaced by a citation having the full set of desired fields obtained from MEDLINE to produce accurate, useful data for consumption by the scientific public. Patents With the advent of patented sequences it became necessary to cite a patent as a bibliographic entity instead of an article. The data model supports a very complete patent citation, a format developed in cooperation with the US Patent Office.

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