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Atlas of Clinical Haematology by Dr. med., Prof. Herbert Begemann, Dr. med., Priv.-Doz.

By Dr. med., Prof. Herbert Begemann, Dr. med., Priv.-Doz. Johann Rastetter (auth.)

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Dest. )J. Rinse with distilled water. Small blue ferruginous granules are present in some of the erythrocytes or the cytoplasm of macro and normoblasts. The erythrocytes are called siderocytes, the erythroblasts sideroblasts. Lupus Erythematosus (LE) Cell Test The LE cell phenomenon refers to neutrophil granulocytes which retain phagocytosed nuclear debris in their cytoplasm. Immunological processes with antibody formation to nuclear proteins playa part in the development of LE cells. Since direct demonstration of LE cells in blood or bone marrow smears is only rarely successful, several direct and indirect methods are employed by which the "Lupus erythematosus factor" responsible for the LE cell phenomenon is demonstrated in the patient's serum.

In the stage of myelocytes, this granulation becomes distinct. - Wright's hypothesis that megakaryocytes are foci for the 24 development of thrombocytes is in general accepted today. The genesis of monocytes has been much discussed in recent years. ). It is held today that the monocytes belong to the myeloid series. It is however not fully ascertained whether they develop directly from promyelocytes or whether a specific precursor, the monoblast, has to be assumed. Classification of the origin of plasma cells and reticulum cells still proves to be extremely difficult.

An example is cell 17 after silver impregnation. However all these cells reveal a fine loose chromatin structure of the nucleus which often contains several, up to 6, nucleoli. e. the cytoplasm has been lost during spreading (8, 11-1S). Occasionally just nuclear shadows are seen (lS). If cytoplasm is present it is not uniformly stained: usually it is slate grey with an irregular and indistinct outline (1-4), sometimes containing fine or somewhat coarse reddish granules (9). These cells were formerly called "Ferrata cells".

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