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Asthma by Frank Coke (Auth.)

By Frank Coke (Auth.)

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Example text

By a lessening of the action of the sympathetic nerve, whereby the vagus is allowed uncontrolled and unbalanced action, causing its normal effect to be multiplied and excessive. 2. — Through t h e nerves of t h e endothelial blood-vessels, as in t h e experimental anaphylactoid reactions. 3. —By substances acting through the blood :— i. In anaphylaxis, the mixture of the reagins in the blood and cells, with free antigen to which they are sensitized, causing the contraction of smooth muscle wherever t h a t is situated and predominantly in the bronchial muscle.

I t is on record t h a t those soldiers who responded to m u s t a r d gas b y an asthmatical seizure escaped d e a t h more commonly t h a n those whose bronchial muscles gave no hindrance to the poison gas reaching the alveoli. B u t the necessity for this use of the bronchial muscle is extremely rare in everyday life, and m u s t have been still ANATOMY AND PHYSIOLOGY 33 more uncommon in man's earlier existence, when he had not to encounter chemical warfare, London fogs, and similar acquisitions of modern civilization.

B u t the necessity for this use of the bronchial muscle is extremely rare in everyday life, and m u s t have been still ANATOMY AND PHYSIOLOGY 33 more uncommon in man's earlier existence, when he had not to encounter chemical warfare, London fogs, and similar acquisitions of modern civilization. Still less can such experiences afford an explanation of the power of the bronchial muscle and its readiness for action in the guinea-pig. I am inclined to think the muscle must take part in every normal respiration, contracting during each expiration.

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