By Fabian Amman, Stephan H. Bernhart (auth.), João C. Setubal, Nalvo F. Almeida (eds.)
This publication constitutes the refereed court cases of the eighth Brazilian Symposium on Bioinformatics, BSB 2013, held in Recife, Brazil, in November 2013. The 18 usual papers awarded have been rigorously reviewed and chosen for inclusion during this ebook. The papers disguise all facets of bioinformatics and computational biology.
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Extra info for Advances in Bioinformatics and Computational Biology: 8th Brazilian Symposium on Bioinformatics, BSB 2013, Recife, Brazil, November 3-7, 2013, Proceedings
Hence, it is important to map the occurrences of SNPs, but that has shown to be a huge challenge. An haplotype can be deﬁned as a set of SNPs from a copy of a speciﬁc chromosome. Much of the diﬃculty of ﬁnding these alterations is due to the lack of haplotype data in large scale, mostly because of the high cost of collecting that information directly. One possible way of acquiring haplotype data is to infer them from genotype data, which are highly abundant. That motivates the Haplotype Inference (HI) problem, whose computational cost depends on the evolutionary model considered.
The ﬁrst excision-reincorporation mimics the interchange of segments d and g, while the second excision-reincorporation mimics the transposition of segment f . e. where DNA segments may be present in one, but not in the other genome. In order to transform one such genome into the other one, insertions and deletions (indels) of segments are necessary, giving rise to the so-called DCJ-indel model [14, 15], for which both the distance and one optimal sorting scenario can be obtained in linear time.
Biopathways representation and simulation on hybrid functional Petri net. In Silico Biol. 3, 389–404 (2003) 21. : A new regulatory interaction suggested by simulations for circadian genetic control mechanism in mammals. J. Bioinform. Comput. Biol. 4, 139–153 (2006) 22. com 23. : Coordination of circadian timing in mammals. Nature 418, 935–941 (2002) 24. : Rhythmic expression of BMAL1 mRNA is altered in Clock mutant mice: diﬀerential regulation in the suprachiasmatic nucleus and peripheral tissues.