By S. Eva Singletary, Geoffrey L. Robb
Edited via notable leaders within the box of breast sickness (Dr. Singletary chairs the Breast melanoma Committee for the yank university of Surgeons), this booklet bargains first-hand suggestion on prevention, prognosis, therapy and reconstruction by way of famous gurus. The paintings positive aspects the non-public remedy protocols of the head physicians and surgeons focusing on breast affliction. stipulations coated comprise benign and malignant tumors, endocrine and anxious problems, and adolescent and grownup difficulties in either men and women. Key gains: - comprises authoritative suggestion according to the scientific event of famous investigators - offers a superb evaluation of breast illness, beginning with breast screening, and advancing to issues reminiscent of silicone autoimmune affliction and breast reconstruction suggestions - Takes a well-rounded method of sufferer remedy, with articles on psychosocial difficulties regarding breast melanoma, and the follow-up care of the breast melanoma sufferer - followed by means of a CD-ROM with the whole textual content and illustrations of the e-book, in totally searchable PDF records viewers: scholars and practitioners in surgical procedure, plastic and reconstructive surgical procedure, oncology, and gynecology.
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Additional info for Advance Therapy of Breast Disease
Specific BRCA-1 and BRCA-2 mutations have been shown to cluster in specific populations: a BRCA-2 mutation in Icelandic individuals, 3 specific BRCA- 1 mutations in the Dutch population, and several among French C a n a d i a n ~ . ~ In~the - ~ ~US, the most prevalent founder mutations occur among individuals of Ashkenazi Jewish descent. 28The marked prevalence in the population means that BRCA-1 and BRCA-2 mutations underlie a higher proportion of breast cancers occurring in this group. Among Jewish women with breast cancer diagnosed before age 43, 20 to 30% will carry 1 of these 3 mutations.
Oncology 1996;10:159-66. 39. Rothenberg K, Fuller B, Rothstein M, et al. Genetic information and the workplace: legislative approaches and policy changes. Science 1997;275: 1755-7. 40. Lerman C, Narod S, Schulman K, et al. BRCA- 1 testing in families with hereditary breast-ovarian cancer: a prospective study of patient decision making and outcomes. J Amer Med Assoc 1996;275:1885-92. 41. Lerman C, Hughes C, Lemon SJ, et al. What you don’t know can hurt you: adverse psychologic effects in members of BRCA- 1-linked and BRCA-2-linked families who decline genetic testing.
A conclusive answer to this question will require additional studies in the future. An evaluation for the presence of predisposing mutations among the women in the BCPT is currently being undertaken and may clarify whether tamoxifen will be effective primary prevention for these women.