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Adult Obesity: A Paediatric Challenge (Frontiers in Life by Linda Voss, Terry Wilkin

By Linda Voss, Terry Wilkin

Whereas it truly is more and more transparent that grownup weight problems starts off in formative years, fighting this is an enormous problem for the pediatrician.Adult weight problems: A Paediatric problem highlights the explanations and effects of weight problems, bringing a contemporary realizing to the remedy of a seriously stigmatized challenge. This choice of essays, in line with displays made at a countrywide symposium on weight problems, makes a speciality of dealing with the situation and its results. international popular authors supply a wide-ranging standpoint of weight problems as an international challenge and discover its devastating metabolic, social, and political impact.Clarifying a couple of very important concerns, this compilation presents solutions to a few of the questions surrounding this risky . It bargains sound suggestion on confronting weight problems and conveys the urgency that this challenge calls for and merits.

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Additional resources for Adult Obesity: A Paediatric Challenge (Frontiers in Life Science)

Sample text

Reasons are numerous, but include a lack of well-conducted studies of candidate genes in large populations with reliable phenotypes. Two general approaches are used in the search for genes underlying common polygenic obesity in humans. The first one focuses on candidate genes, that is, genes having some plausible role in obesity, based on their known or presumed biological role in energy homeostasis. Efforts to identify candidate genes for obesity first concentrated on adipose tissue. In brown adipose tissue, regulation of thermogenesis by the sympathetic nervous system is mediated by β-adrenergic receptors (Nonogaki, 2000).

Nature, 372: 425–32. Zollner, S. and Von Haeseler, A. (2000) A coalescent approach to study linkage disequilibrium between single-nucleotide polymorphisms. Am J Hum Genet, 66: 615–28. The seeds are sown in childhood 4 39 The seeds are sown in childhood Terry Wilkin Earlier chapters in this book have covered the global nature of obesity, the relationship between physical activity and food intake and some exciting developments in the genetics of obesity. This chapter will try to link obesity with some of the problems that result from it by exploring the underlying mechanisms that affect health.

Cushing’s disease, characterized by disturbance of the HPA axis and hypercortisolaemia, is an unexpected model for metabolic syndrome, with abdominal obesity and insulin resistance as central features. 44 Terry Wilkin The third message, therefore – and an important one clinically – is that total fat is not the cause of insulin resistance. , 1998; Montague and O’Rahilly, 2000). BMI is widely used as a measure of fatness. Importantly, however, it is not a measure of fat distribution. When does insulin resistance begin?

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