Press "Enter" to skip to content

Adrenal disease in childhood: clinical and molecular aspects by I.A. Hughes, A.J.L. Clark, P.-E. Mullis

By I.A. Hughes, A.J.L. Clark, P.-E. Mullis

Adrenal sickness in youngsters poses an immensely tough diagnostic and administration challenge for the paediatrician in view of the massive variety of infrequent pathologies which could found in this manner. This quantity brings jointly the services of the said leaders in particular adrenal problems to supply a effectively available textual content that mixes a close description of the molecular origins of those illnesses, as they're presently understood, with a distinct account of the medical positive factors and healing strategies. starting with issues that essentially impact adrenal improvement and progressing in the direction of the defects that intervene with steroid construction, the reader earnings significant perception into the conventional body structure of the adrenal cortex fairly as published by means of medical problems. the key contributions of contemporary biochemistry and molecular genetics in our present figuring out are seen all through, offering a different review of adrenocortical biology.

Show description

Read Online or Download Adrenal disease in childhood: clinical and molecular aspects (Endocrine Development Vol. 2) PDF

Similar endocrinology books

The Thyroid Sourcebook (5th Edition) (Sourcebooks)

The vintage reference advisor for residing with thyroid disorder--now thoroughly revised and up to date the recent York instances referred to as this booklet "an very good resource of knowledge. " The Thyroid Sourcebook positive aspects sufferer narratives; details at the problems of hypo- and hyperthyroidism, comparable to melancholy, weight achieve, thyroid, eye disorder, and sleep problems; the newest on complimentary medication; and masses extra.

Yen & Jaffe's Reproductive Endocrinology. Physiology, Pathophysiology, and Clinical Management

Yen Jaffe's Reproductive Endocrinology is helping you effectively diagnose and deal with the spectrum of male and female reproductive approach illnesses, from impaired fertility, infertility, and recurrent being pregnant loss via difficulties of sexual improvement, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive getting older.

Infertility: A Clinician’s Guide to Diagnosis and Treatment

A bit over 12 years in the past I wrote a small quantity entitled Infertility. It appeared to me at the moment that major advances within the box referred to as for the e-book of any such quantity. the subsequent is from the preface to that quantity: prior to now 15 years significant growth has been made within the box of infertility prognosis and administration.

Extra info for Adrenal disease in childhood: clinical and molecular aspects (Endocrine Development Vol. 2)

Sample text

Linkage analysis indicates that the triple A gene is located on the long arm of chromosome 12 between the markers D12S368 and D12S1586, a region that contains the keratin type II gene cluster, but no other strong candidate genes for this disorder. characterised unrelated pedigrees with several affected members, we undertook linkage studies with 345 polymorphic markers scattered evenly throughout the human genome. Significant linkage was found to a region on the long arm of chromosome 12 (12q13), close to the keratin type II gene cluster [38] (fig.

Nat Genet 1998;20:353–357. Swain A, Narvaez V, Burgoyne P, Camerino G, Lovell-Badge R: Dax1 antagonizes Sry action in mammalian sex determination. Nature 1998;391:761–767. Kreidberg A, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R: WT-1 is required for early kidney development. Cell 1993;74:679–691. Sikl H: Addison’s disease due to congenital hypoplasia of the adrenals in an infant aged 33 days. J Pathol Bacteriol 1948;60:323–324. Uttley WS: Familial congenital adrenal hypoplasia.

Mol Endocrinol 1996;10:147–158. Duval DL, Nelson SE, Clay CM: A binding site for steroidogenic factor-1 is part of a complex enhancer that mediates expression of the murine gonadotropin-releasing hormone receptor gene. Biol Reprod 1997;56:160–168. Bogerd A, Rice DA, Franklin A, Schimmer BP, Parker KL: Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 -hydroxylase. Mol Endocrinol 1990;4:845–850. Barnhart KM, Mellon PL: The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone alpha-subunit gene in pituitary gonadotropes.

Download PDF sample

Rated 4.62 of 5 – based on 32 votes